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Merck
CN

8.52006

Sigma-Aldrich

Fmoc-Cys(Acm)-OH

≥99.0% (HPLC), for peptide synthesis, Novabiochem®

Synonym(s):

Fmoc-Cys(Acm)-OH, N-α-Fmoc-S-acetamidomethyl-L-cysteine

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200 ML
CN¥398.69

CN¥398.69


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200 ML
CN¥398.69

About This Item

Empirical Formula (Hill Notation):
C21H22N2O5S
CAS Number:
Molecular Weight:
414.47
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22

CN¥398.69


Available to ship onApril 14, 2025Details


Request a Bulk Order

Product Name

Fmoc-Cys(Acm)-OH, Novabiochem®

Quality Level

product line

Novabiochem®

Assay

≥96.0% (acidimetric)
≥98% (TLC)
≥99.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

147-150 °C

application(s)

peptide synthesis

functional group

thiol

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This Item
HT1079HT107HT109
density

1.044 g/mL at 20 °C

density

-

density

-

density

-

impurities

chloral hydrate

impurities

-

impurities

-

impurities

-

General description

The side-chain Acm group is stable to TFA but can be removed with Hg(II) [1] or Ag(I) [2] to give cysteinyl peptides, or oxidatively with Tl(III) [3] or I2 [4] to generate cystinyl peptides.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

[1] D. F. Veber, et al. (1972) J. Am. Chem. Soc., 94, 5456.
[2] M. Yoshida, et al. (1990) Chem. Pharm. Bull., 38, 273.
[3] N. Fujii, et al. (1987) Chem. Pharm. Bull., 36, 2339.
[4] B. Kamber, et al. (1980) Helv. Chim. Acta, 63, 899.

Linkage

Replaces: 04-12-1014

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011B)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (25 mmole in 50 ml DMF): clearly soluble
UV/VIS (E(450 bis 600 nm)): ≤ 50 mAU
Assay (acidimetric): ≥ 96.0 %
Water (K. F.): ≤ 5.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Protocols

Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.

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