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Merck
CN

8.51200

DOTA-tris(tert-butyl ester)

Novabiochem®

Synonym(s):

DOTA-tris(tert-butyl ester), Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate

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About This Item

Empirical Formula (Hill Notation):
C28H52N4O8
CAS Number:
137076-54-1
Molecular Weight:
572.73
UNSPSC Code:
12352108
MDL number:
MFCD02259697

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Product Name

DOTA-tris(tert-butyl ester), Novabiochem®

InChI

1S/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34)

InChI key

RVUXZXMKYMSWOM-UHFFFAOYSA-N

product line

Novabiochem®

form

powder

reaction suitability

reagent type: fluorescent-labelling reagent

manufacturer/tradename

Novabiochem®

mp

88-93 °C

application(s)

peptide synthesis

storage temp.

2-8°C

Quality Level

200

Analysis Note

Colour (visual): white to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (NMR): ≥ 95.0 %
Identity (NMR): passes test
NMR-spectrum: passes test

General description

The most convenient reagent for the labeling of a peptide with DOTA [1]. This reagent has good solubility in DMF and DCM, and its free carboxyl group can be easily activated using uronium or phosphonium coupling reagents, enabling it to be attached to peptide amino groups. Removal of the t-butyl ester groups from the DOTA occurs during the course of the TFA-mediated cleavage reaction. The progress of the reaction should be monitored as the cleavage of these esters is slow, owing to the proximity of the basic ring nitrogens.

Literature references

[1] L. M. De León-Rodrýguez & Z. Kovacs (2008) Bioconjugate Chem, 19, 391.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_c

Not applicable

Regulatory Information

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