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8.51061

Sigma-Aldrich

2-Chlorotrityl chloride

Novabiochem®

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Synonym(s):
2-Chlorotrityl chloride
Empirical Formula (Hill Notation):
C19H14Cl2
CAS Number:
42074-68-0
Molecular Weight:
313.22
MDL number:
MFCD00040399
UNSPSC Code:
12352107
EC Index Number:
255-647-3
NACRES:
NA.22

Quality Level

200

product line

Novabiochem®

Assay

≥95.0% (HPLC)

form

powder

manufacturer/tradename

Novabiochem®

mp

133.0-137.0 °C

application(s)

peptide synthesis

storage temp.

2-30°C

InChI

1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H

InChI key

JFLSOKIMYBSASW-UHFFFAOYSA-N

Related Categories

General description

Hyperacid-labile ester protecting group [1]. Introduced under extremely mild conditions by reacting together the acid, trityl chloride and DIPEA in DCM. Ideal for the protection of the C-terminal carboxylic acid group of C-terminal protected peptide fragments, monoprotection of diacids and as a general carboxylic acid protecting group in organic synthesis.


Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Literature references

[1] P. Athanassopoulos, et al. (1995) Tetrahedron Lett., 36, 5645.

Linkage

Replaces: 01-63-0045

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Melting range (lower value): ≥ 133 °C
Melting range (upper value): ≤ 137 °C
Assay (HPLC, area%): ≥ 95.0 % (a/a)

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Warning

Hazard Statements

H290 - H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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