8.43943
Propanephosphonic acid anhydride
(50% solution in 2-Methyltetrahydrofuran) for synthesis T3P
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Synonym(s):
2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution, PPACA, Propylphosphonic anhydride, T3P
UNSPSC Code:
12352108
NACRES:
NA.22
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Quality Level
form
liquid
bp
78-80 °C/1013 hPa (solvent)
transition temp
flash point -11 °C (solvent)
density
1.039 g/cm3 at 20 °C
storage temp.
2-8°C
Application
- Study on the propylphosphonic anhydride (T3P) mediated Ugi-type three-component reaction. Efficient synthesis of an α-amino amide library: Explores the use of T3P in a three-component Ugi reaction, demonstrating its utility in synthesizing a diverse library of α-amino amides (Milen et al., 2017).
- Cyclization of Linear Tetrapeptides Containing N‐Methylated Amino Acids by using 1‐Propanephosphonic Acid Anhydride: Reports the unexpected findings during the cyclization of linear tetrapeptides, where T3P played a crucial role in enhancing the reaction outcomes (Zhang et al., 2017).
Analysis Note
Assay (T3P) (NMR): ≥ 40.0 %
Pyropropanephosphonic acid (NMR): ≤ 10.0 %
Propanephosphonic acid (NMR): ≤ 0.50 %
2- Methyltetrahydrofurane (calculated): ≤ 50.0 %
Pyropropanephosphonic acid (NMR): ≤ 10.0 %
Propanephosphonic acid (NMR): ≤ 0.50 %
2- Methyltetrahydrofurane (calculated): ≤ 50.0 %
Regulatory Information
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