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8.21092

Sigma-Aldrich

Tetrahydrofurfuryl alcohol polyethylene glycol ether

for synthesis

Synonym(s):

Tetrahydrofurfuryl alcohol polyethylene glycol ether, Glycofurol

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352104
NACRES:
NA.22

Quality Level

form

liquid

bp

176 °C/40 hPa

density

1.08 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2

InChI key

CTPDSKVQLSDPLC-UHFFFAOYSA-N

Application


  • Biodegradable microparticle production: A novel green process employing CO2 medium was developed for the production of biodegradable microparticles encapsulating TGF-beta1, utilizing tetrahydrofurfuryl alcohol polyethylene glycol ether, enhancing the sustained release properties of the therapeutic proteins (Swed et al., 2015).

  • Nanocarrier devices for targeted drug delivery: Tetrahydrofurfuryl alcohol polyethylene glycol ether was utilized in the formulation of photosensitizer-loaded nanocarrier devices, bridging laboratory and large-scale production, and demonstrating potential in targeted drug delivery systems (Beyer et al., 2015).

  • Cardiac tissue-engineering: In cardiac tissue engineering, tetrahydrofurfuryl alcohol polyethylene glycol ether was incorporated into a thermosensitive hydrogel for releasing growth factors from pharmacologically active microcarriers, presenting a biomimetic 3D scaffold that supports cardiac cell growth (Karam et al., 2014).

  • Enhanced pharmacokinetics in drug delivery: A self-microemulsifying drug delivery system incorporating tetrahydrofurfuryl alcohol polyethylene glycol ether demonstrated improved pharmacokinetics for tacrolimus, suggesting its efficacy in bioavailability enhancement (von Suesskind-Schwendi et al., 2013).

Analysis Note

Density (d 20 °C/ 4 °C): 1.080 - 1.090
Identity (IR): passes test

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

275.0 °F - closed cup

Flash Point(C)

135 °C - closed cup


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