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Safety Information

8.17043

SAFC

Thimerosal

EMPROVE® ESSENTIAL, Ph. Eur., BP

Pharma Manufacturing

Synonym(s):

Thimerosal

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About This Item

Empirical Formula (Hill Notation):
C9H9HgNaO2S
CAS Number:
Molecular Weight:
404.81
MDL number:
UNSPSC Code:
12352103
EC Index Number:
200-210-4

Agency

BP
Ph. Eur.

Quality Level

product line

EMPROVE® ESSENTIAL

form

solid

pH

6.7 (20 °C, 10 g/L in H2O)

mp

232-233 °C (decomposition)

transition temp

flash point 250 °C

solubility

1000 g/L

application(s)

liquid formulation
ophthalmics
pharma/biopharma processes
pharmaceutical
semi-solid formulation

storage temp.

15-25°C

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Thimerosal has strong antiseptic and antifungal capabilities and is therefore typically used as preservative in liquid dosage forms of cosmetics and pharmaceutical products.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

As part of the corporation global plan to support the MinamataConvention in eliminating mercury-containing compounds, as of January 2021customers will be required to provide an End-Use Declaration. The sales ofthimerosal will be restricted for approved applications only, such aspreservative in vaccine manufacturing, preservative in eye cosmetics, researchuse within academia (excluding preservation intent) and as reference materialonly. The product is not intended for use as a biocide under global biocideregulations, including but not limited to US EPA′s Federal InsecticideFungicide and Rodenticide Act , European Biocidal Products Regulation, Canada’sPest Management Regulatory Agency, Turkey’s BiocidalProducts Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

Target Organs

Kidney

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

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