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Sigma-Aldrich

Brij® 58

for synthesis

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Synonym(s):
Brij® 58, Polyoxyethylene (20) cetylether, Polyethyleneglycol (20) cetylether
Linear Formula:
HO-(CH2CH2O)n-(CH2)15-CH3
CAS Number:
9004-95-9
MDL number:
MFCD00080892
UNSPSC Code:
12352104
EC Index Number:
500-014-1
NACRES:
NA.22

Quality Level

200

form

solid

potency

2500 mg/kg LD50, oral (Rat)

mp

38-42 °C

transition temp

flash point >149 °C

storage temp.

2-30°C

InChI

1S/C56H114O21/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-58-19-21-60-23-25-62-27-29-64-31-33-66-35-37-68-39-41-70-43-45-72-47-49-74-51-53-76-55-56-77-54-52-75-50-48-73-46-44-71-42-40-69-38-36-67-34-32-65-30-28-63-26-24-61-22-20-59-18-16-57/h57H,2-56H2,1H3

InChI key

NLMKTBGFQGKQEV-UHFFFAOYSA-N

Application

  • Potential Activity of Micafungin and Amphotericin B Co-Encapsulated in Nanoemulsion against Systemic Candida auris Infection in a Mice Model.: This study investigates the use of Brij® 58 in formulating a nanoemulsion to enhance the efficacy of micafungin and amphotericin B against systemic Candida auris infections in mice. The results suggest significant improvements in drug delivery and antifungal activity (Marena et al., 2024).
  • Encapsulation of Pure Water-Stable Perovskite Nanocrystals (PNCs) into Biological Environment-Stable PNCs for Cell Imaging.: This research highlights the role of Brij® 58 in stabilizing perovskite nanocrystals, enhancing their stability and applicability in biological environments for cell imaging purposes (Zheng et al., 2024).
  • Improving Drug Delivery on Candida Albicans Using Geraniol Nanoemulsion.: This paper discusses the use of Brij® 58 in geraniol nanoemulsions to enhance drug delivery against Candida albicans, showing improved antifungal effectiveness and stability (Silva Pontes et al., 2023).
  • Combined Effect of Shaking Orbit and Vial Orientation on the Agitation-Induced Aggregation of Proteins.: Brij® 58 is utilized in this study to prevent protein aggregation in pharmaceutical formulations during agitation, highlighting its importance in maintaining protein stability (Dasnoy et al., 2024).

Analysis Note

Hydroxyl value: 45 - 60
Water (K. F.): ≤ 3.0 %
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Legal Information

Brij is a registered trademark of Croda International PLC

Pictograms

Environment
GHS09

Hazard Statements

H411

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

302.0 °F - closed cup

Flash Point(C)

150 °C - closed cup

Certificates of Analysis (COA)

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