All Photos(1)
Synonym(s):
Poly(ethylene glycol), Polyethylene glycol 6000, Polyglycol, Polyethylene oxide, Polyoxy ethylene, PEG 6000, PEG
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
UNSPSC Code:
13111021
EC Index Number:
500-038-2
NACRES:
NA.22
Recommended Products
vapor pressure
<0.01 hPa ( 20 °C)
Quality Level
form
solid
autoignition temp.
420 °C
potency
28000 mg/kg LD50, oral (Rat)
>20000 mg/kg LD50, skin (Rabbit)
pH
5-7 (20 °C, 100 g/L in H2O)
mp
58-63 °C
transition temp
flash point 270 °C
density
1.2 g/cm3 at 20 °C
storage temp.
2-30°C
SMILES string
C(CO)O
InChI
1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI key
LYCAIKOWRPUZTN-UHFFFAOYSA-N
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General description
Polyethylene glycol (PEG) is a synthetic, hydrophilic, biocompatible polymer that has a wide range of uses in PEGylation, surface conjugation, nanoparticle coating, and crosslinking for hydrogels, etc. PEGs are made by polymerizing ethylene oxide via a ring-opening reaction to produce a wide range of molecular weights and molecular weight distributions (polydispersity).
Application
Polyethylene glycol 6000 is a non-ionic surfactant that can be used as a structure-directing agent to prepare mesoporous γ-Al2O3. PEG 6000 induced the formation of the lamellate structure morphology of boehmite nanoparticles with improved textural properties such as high surface area, larger pore volume, and pore size. It is also used in drug formulations to enhance the dissolution rate of the poorly water-soluble drug molecule. PEG-6000 can also be used in the purification of nucleic acids via the selective precipitation method. This approach is economically cost-effective and faster than the commonly employed chromatographic purification method.
Analysis Note
Melting range (lower value): ≥ 59 °C
Melting range (upper value): ≤ 64 °C
Hydroxyl value: 16 - 23
Average molecular mass: 5000 - 7000
Identity (IR): passes test
Melting range (upper value): ≤ 64 °C
Hydroxyl value: 16 - 23
Average molecular mass: 5000 - 7000
Identity (IR): passes test
WGK
WGK 1
Certificates of Analysis (COA)
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Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000.
S Biswal et al.
AAPS PharmSciTech, 9(2), 563-570 (2008-05-07)
The aim of the present study was to enhance the dissolution rate of gliclazide using its solid dispersions (SDs) with polyethylene glycol (PEG) 6000. The phase solubility behavior of gliclazide in presence of various concentrations of PEG 6000 in 0.1
A facile rout to synthesis lamellate structure mesoporous alumina using polyethylene glycol 6000 (PEG, molecular weight= 6000) as structure directing agent
Su Ai-ping, et al.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 159, 36-41 (2012)
S Verheyen et al.
International journal of pharmaceutics, 249(1-2), 45-58 (2002-11-16)
Solid dispersion literature, describing the mechanism of dissolution of drug-polyethylene glycol dispersions, still shows some gaps; (A). only few studies include experiments evaluating solid solution formation and the particle size of the drug in the dispersion particles, two factors that
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