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8.03456

Sigma-Aldrich

1,4-Diazabicyclo[2.2.2]octane

greener alternative

for synthesis

Synonym(s):

1,4-Diazabicyclo[2.2.2]octane, Triethylenediamine, DABCO

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About This Item

Empirical Formula (Hill Notation):
C6H12N2
CAS Number:
280-57-9
Molecular Weight:
112.17
MDL number:
MFCD00006689
UNSPSC Code:
12352005
EC Index Number:
205-999-9
NACRES:
NA.22

vapor pressure

0.68 hPa ( 21 °C)

Quality Level

200

Assay

≥98.0% (GC)

form

solid

autoignition temp.

350 °C

potency

700 mg/kg LD50, oral (Rat)

greener alternative product characteristics

Catalysis
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sustainability

Greener Alternative Product

bp

173.4 °C/1000 hPa

mp

155-158 °C

transition temp

flash point 62.2 °C

solubility

400 g/L

density

1.14 g/cm3 at 25 °C

bulk density

800 kg/m3

greener alternative category

Aligned,

storage temp.

2-30°C

InChI

1S/C6H12N2/c1-2-8-5-3-7(1)4-6-8/h1-6H2

InChI key

IMNIMPAHZVJRPE-UHFFFAOYSA-N

Related Categories

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalytic efficiency. Click here for more information.

Application

  • Biocompatible Polymer Composites: Research demonstrates the development of a reactive compatibilization method using 1,4-diazabicyclo[2.2.2]octane as a catalyst for the preparation of polylactic acid/poly(butylene adipate-co-terephthalate)/thermoplastic starch ternary bio-composites. This approach significantly improves the mechanical and biodegradable properties of the composites, suitable for environmentally friendly applications in the packaging and automotive industries (Fang et al., 2024).
  • Cobalt Single-Atom Catalysts: Research on the development of cobalt single-atom catalysts encapsulated in a metal-organic framework using 1,4-diazabicyclo[2.2.2]octane. This catalyst shows exceptional efficiency in the oxygen reduction reaction, important for energy conversion technologies such as fuel cells and metal-air batteries (Gao et al., 2024).
  • Advanced Analytical Techniques: Study on the use of 1,4-diazabicyclo[2.2.2]octane in advanced derivatization techniques for the analysis of Novichok agents in biofluids using LC-MS. This research contributes to the field of forensic science and chemical warfare agent detection, providing robust methods for emergency responses and public safety (Yamaguchi et al., 2023).

Analysis Note

Assay (GC, area%): ≥ 98.0 % (a/a)
Water (K. F.): ≤ 1.0 %
Identity (IR): passes test

Signal Word

Danger

Hazard Statements

H228 - H302 - H315 - H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Sol. 1 - Skin Irrit. 2

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 1

Flash Point(F)

144.0 °F - closed cup

Flash Point(C)

62.2 °C - closed cup

Certificates of Analysis (COA)

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Yashwanth Ashok et al.
ACS infectious diseases, 6(4), 588-602 (2020-01-04)
The targeted pathogen-selective approach to drug development holds promise to minimize collateral damage to the beneficial microbiome. The AB5-topology pertussis toxin (PtxS1-S5) is a major virulence factor of Bordetella pertussis, the causative agent of the highly contagious respiratory disease whooping
Praveen Bathini et al.
Neurobiology of aging, 76, 80-95 (2019-02-02)
Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases. Nevertheless, very little is known about the pathophysiological changes underlying smell loss that may reflect early network dysfunction. A cross-sectional histoanatomical study

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