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8.03235

Sigma-Aldrich

N,N-Dimethylacetamide

for synthesis

Synonym(s):

N,N-Dimethylacetamide, Acetic acid dimethylamide, Acetyldimethylamine, DMA

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About This Item

Linear Formula:
CH3CON(CH3)2
CAS Number:
127-19-5
Molecular Weight:
87.12
MDL number:
MFCD00008686
UNSPSC Code:
12352111
EC Index Number:
204-826-4
NACRES:
NA.22

vapor pressure

1.76 hPa ( 20 °C)

Quality Level

200

Assay

≥99% (GC)

form

liquid

autoignition temp.

400 °C

potency

5830 mg/kg LD50, oral (Rat)

expl. lim.

1.7-11.5 % (v/v)

pH

4 (20 °C, 200 g/L in H2O)

bp

165-166 °C/1013 hPa

mp

-20 °C

transition temp

flash point 64 °C

solubility

soluble >1000 g/L

density

0.94 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/C4H9NO/c1-4(6)5(2)3/h1-3H3

InChI key

FXHOOIRPVKKKFG-UHFFFAOYSA-N

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General description

N,N-Dimethylacetamide (DMAc) is a water-miscible organic solvent used in the synthesis of styrene, vinyl resin, linear polyester, acrylic fiber, plastic, pesticide, and synthetic leather. It participates in dehydrogenation, dehydration, halogenation, deprotonation reactions and reductive carbonylation of transition metals. It can also act as catalysts, promoters, halogen/alkoxy or hydroxyl/halogen exchange mediators, reducing agents, and sources of the base.

Application

N,N-Dimethylacetamide is used as a solvent:
  • In the synthesis of poly(amide-hydrazide)s–graphene composites.
  • In the synthesis of N,N′-1,2-ethanediylbis-(4-hydroxy-pentanamide) and 4-hydroxy-N-(2- hydroxyethyl)-pentanamide based polyurethanes in presence of triethylamine catalyst.

Features and Benefits

N,N-Dimethylacetamide has :
  • High dissolution power of various substrate. 
  • High capacity to solvate anions.

Analysis Note

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.940 - 0.942
Water (K. F.): ≤ 0.30 %
Identity (IR): passes test

Pictograms

Exclamation markHealth hazard
GHS07,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

147.2 °F - closed cup

Flash Point(C)

64 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N,N-Dimethylformamide and?N,N-Dimethylacetamide as Carbon, Hydrogen, Nitrogen, and/or Oxygen Sources
Jean LB, et al.
Solvents as Reagents in Organic Synthesis: Reactions and Applications (2017)
Poly (amide-hydrazide) s--graphene composites synthesis and characterization
Elsabee MZ, et al.
Polymer Composites, 38(7), 1311-1318 (2017)
Toxic hepatitis in occupational exposure to solvents
Malaguarnera G.et al.
World Journal of Gastroenterology, 18(22), 2756-2756 (2012)
Synthesis and characterization of novel polyurethanes based on N, N'-1, 2-ethanediylbis-(4-hydroxy-pentanamide) and 4-hydroxy-N-(2-hydroxyethyl)-pentanamide
Chalid M
Advanced Materials Research, 277, 112-119 (2011)

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