681674
Wnt Pathway Inhibitor XI, CCT036477
The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.
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Synonym(s):
Wnt Pathway Inhibitor XI, CCT036477, CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
Empirical Formula (Hill Notation):
C21H18ClN3
CAS Number:
Molecular Weight:
347.84
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥95% (1H-NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
InChI key
IFOHRIXRQPOHQZ-UHFFFAOYSA-N
General description
A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ewan, K., et al. 2010. Cancer Res.70, 5963.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Certificates of Analysis (COA)
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