681636-M
W-13, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).
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Synonym(s):
W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
Empirical Formula (Hill Notation):
C14H17ClN2O2S · xHCl
CAS Number:
Molecular Weight:
312.81 (free base basis)
MDL number:
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
water: 35 mg/mL
storage temp.
2-8°C
InChI
1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
InChI key
QKAALLVQBOLELJ-UHFFFAOYSA-N
General description
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).
Biochem/physiol Actions
Target IC50: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase
Warning
Toxicity: Standard Handling (A)
Analysis Note
single spot by TLC
Other Notes
Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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