662088
UCH-L1 Inhibitor II
The UCH-L1 Inhibitor II, also referenced under CAS 439946-22-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
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UCH-L1 Inhibitor II, Ubiquitin C-terminal Hydrolase-L1 Inhibitor II, 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid, LDN-91946
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Assay
≥85% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
brown
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
General description
A thienopyridinone compound that inhibits UCH-L1-catalyzed substrate hydrolysis (Ki app = 2.8 µM with Ub-AMC as the substrate) in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme, while exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 µM.
The UCH-L1 Inhibitor II, also referenced under CAS 439946-22-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Mermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett.17, 3729.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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