662047
Anti-Uncoupling Protein-2 (UCP-2) (144-157) Rabbit pAb
liquid, Calbiochem®
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UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
0.1% sodium azide as preservative
species reactivity
human, mouse, rat
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG
shipped in
wet ice
storage temp.
−70°C
target post-translational modification
unmodified
Gene Information
human ... UCP2(7351)
General description
Protein A purified rabbit polyclonal antibody. Recognizes the UCP-2 protein.
Recognizes the UCP-2 protein.
Immunogen
a synthetic peptide [(C)QARAGGGRRYQSTV] corresponding to amino acids 144-157 of human and mouse UCP-2
Application
ELISA (1:100,000)
Immunoblotting (1:1000)
Immunocytochemistry (1:500)
Immunoblotting (1:1000)
Immunocytochemistry (1:500)
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Other Notes
Does not react with UCP-1 or UCP-3. Since this antigen sequence is highly conserved, cross-reactivity across a broad range of species is expected. Variables associated with assay conditions will dictate the proper working dilution.
Stuart, J.A., et al. 2001. J. Biol. Chem.276, 18633.
Gimeno, R.E., et al. 1997. Diabetes46, 900.
Gimeno, R.E., et al. 1997. Diabetes46, 900.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Certificates of Analysis (COA)
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Jan Ježek et al.
Antioxidants & redox signaling, 23(12), 958-972 (2015-05-01)
Pancreatic β-cell chronic lipotoxicity evolves from acute free fatty acid (FA)-mediated oxidative stress, unprotected by antioxidant mechanisms. Since mitochondrial uncoupling protein-2 (UCP2) plays antioxidant and insulin-regulating roles in pancreatic β-cells, we tested our hypothesis, that UCP2-mediated uncoupling attenuating mitochondrial superoxide
P Brauner et al.
Pediatric research, 49(3), 440-447 (2001-03-03)
Hepatic hematopoiesis is prominent during fetal life and ceases around birth. In rodent liver, the decline of the hepatic hematopoiesis starts abruptly at birth being accompanied by a decrease of mitochondrial uncoupling protein 2 (UCP2) expression in monocytes/macrophages, whereas hepatocytes
Jay D Turner et al.
Circulation research, 106(4), 730-738 (2010-01-09)
Uncoupling protein (UCP)2 is a mitochondrial inner membrane protein that is expressed in mammalian myocardium under normal conditions and upregulated in pathological states such as heart failure. UCP2 is thought to protect cardiomyocytes against oxidative stress by dissipating the mitochondrial
Anjum Dihingia et al.
Scientific reports, 8(1), 10021-10021 (2018-07-04)
This study for the first time examined the prophylactic role of Tungrymbai, a well-known fermented soybean food of North-East India, against hepatic steatosis. Treatment with hexane-isopropanolic (2:1, HIET) but not hydro-alcoholic (70% ethanol, HAET) extract dose-dependently (0.1, 0.2, or 0.3 µg/mL)
C Y Zhang et al.
Cell, 105(6), 745-755 (2001-07-07)
beta cells sense glucose through its metabolism and the resulting increase in ATP, which subsequently stimulates insulin secretion. Uncoupling protein-2 (UCP2) mediates mitochondrial proton leak, decreasing ATP production. In the present study, we assessed UCP2's role in regulating insulin secretion.
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