657021
Tyrosine Kinase Inhibitor Set II
The Tyrosine Kinase Inhibitor Set II controls the biological activity of Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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About This Item
UNSPSC Code:
12352200
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
shipped in
ambient
storage temp.
−20°C
General description
Contains 20 mg of Genistein (Cat. No. 345834), 1 mg of PP2 (Cat. No. 529573), 5 mg of AG 490 (Cat. No. 658401), 5 mg of AG 1296 (Cat. No. 658551), and 5 mg of AG 1478 (Cat. No. 658552). Supplied with an informational insert.
Protein tyrosine phosphorylation is a key element in several membrane signal transduction systems. There are two general classes of tyrosine kinases: the receptor tyrosine kinases and the receptor-associated tyrosine kinases. The receptor tyrosine kinases possess an extracellular ligand binding domain and an intracellular catalytic domain with intrinsic tyrosine kinase activity. The receptor-associated tyrosine kinases transmit signals from the membrane by interacting with the cytoplasmic domain of membrane proteins.
The design of specific inhibitors of tyrosine kinases is important for both fundamental research and for developing therapeutic strategies for the treatment of cancer, atherosclerosis, psoriasis, septic shock, and other disorders where increased tyrosine kinase activity has been reported.
The Tyrosine Kinase Inhibitor Set contains a general tyrosine kinase inhibitor and a series of other inhibitors, which are selective for various tyrosine kinases that are important in cellular signaling. The set contents and characteristics are listed in the table below.
The design of specific inhibitors of tyrosine kinases is important for both fundamental research and for developing therapeutic strategies for the treatment of cancer, atherosclerosis, psoriasis, septic shock, and other disorders where increased tyrosine kinase activity has been reported.
The Tyrosine Kinase Inhibitor Set contains a general tyrosine kinase inhibitor and a series of other inhibitors, which are selective for various tyrosine kinases that are important in cellular signaling. The set contents and characteristics are listed in the table below.
Biochem/physiol Actions
Product competes with ATP.
Secondary Target
PKC, Src family of protein tyrosine kinases, JAK2
PKC, Src family of protein tyrosine kinases, JAK2
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Preparation Note
Concentrated solutions of ≥1 mg/ml should be prepared in anhydrous DMSO.
Other Notes
Hanke, J.H., et al. 1996. J. Biol. Chem.271 695.
Meydan, N., et al. 1996. Nature379, 645.
Levitzi, A., and Gazit, A. 1995. Science267, 1782.
Akiyama, T., et al. 1987. J. Biol. Chem.262, 5592.
Meydan, N., et al. 1996. Nature379, 645.
Levitzi, A., and Gazit, A. 1995. Science267, 1782.
Akiyama, T., et al. 1987. J. Biol. Chem.262, 5592.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Certificates of Analysis (COA)
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