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647950-M

Millipore

Triclosan

A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase.

Synonym(s):

Triclosan, 5-Chloro-2-(2,4-dichlorophenoxy)phenol

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About This Item

Empirical Formula (Hill Notation):
C12H7Cl3O2
CAS Number:
3380-34-5
Molecular Weight:
289.54
MDL number:
MFCD00800992
UNSPSC Code:
12352200

Quality Level

100

Assay

≥97% (HPLC)

form

crystalline powder
powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL
ethanol: 50 mg/mL

storage temp.

−20°C

InChI

1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H

InChI key

XEFQLINVKFYRCS-UHFFFAOYSA-N

General description

A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fab l encoded enoyl-acyl carrier protein (ACP) reductase. A slow binding inhibitor that forms a stable ternary complex (bsFabl.NAD+. triclosan) in Bacillus subtilis. Also inhibits the growth of Plasmodium falciparum by inhibiting the apicomplexan Fab I (IC50 = 154.4 ng/ml for W2 strain and 387 ng/ml for D6 strain).
A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase. A slow-binding inhibitor that forms a stable ternary complex (bsFabl.NAD+.triclosan) in Bacillus subtilis.

Warning

Toxicity: Environmental Hazard (N)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

McLeod, R., et al. 2001. Int. J. Parasitology31, 109.
Surolia, N. and Surolia, A., 2001. Nat. Medicine7, 167.
Heath, R.J., et al. 2000. J. Biol. Chem.275, 4654.
Heath, R.J., et al. 1999. J. Biol. Chem.274, 11110.
Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol.181, 5489.
Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
McMurray, L.M., et al. 1998. Nature394, 531.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H319,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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