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Merck
CN

614350

Tomatidine, HCl

A steroidal alkaloid that structurally resembles Cyclopamine, but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-teratogenic.

Synonym(s):

Tomatidine, HCl

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About This Item

Empirical Formula (Hill Notation):
C27H45NO2 · xHCl
CAS Number:
6192-62-7
Molecular Weight:
415.65 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00133866

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Product Name

Tomatidine, HCl, A steroidal alkaloid that structurally resembles Cyclopamine, but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-teratogenic.

InChI

1S/C27H45NO2.ClH/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4;/h16-24,28-29H,5-15H2,1-4H3;1H/t16-,17-,18-,19-,20+,21-,22-,23-,24-,25-,26-,27+;/m0./s1

InChI key

SXXHVPYRDFJKPG-XRWUXUKGSA-N

assay

≥90% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

off-white

solubility

DMF: 2 mg/mL
DMSO: 2 mg/mL
ethanol: 2.5 mg/mL
chloroform: methanol (1:1): 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Negative control for Shh (Sonic Hedgehog) signaling
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-teratogenic.

Other Notes

Berman, D.M., et al. 2003. Nature,425, 846.
Thayer, S.P., et al. 2003. Nature,425, 851.
Watkins, D.N., et al. 2003. Nature422, 313.
Cooper, M.K., et al. 1998. Science280, 1603.
Kim, S.K. and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA95, 13036.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Slight warming may be required to achieve complete solubilization.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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