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612084

Sigma-Aldrich

TIMP-2, Human Rheumatoid Synovial Fibroblast

Native TIMP-2 from human rheumatoid synovial fibroblast.

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Synonym(s):
Tissue Inhibitor of Metalloproteinase-2
UNSPSC Code:
12352202

Quality Level

100

Assay

≥90% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

General description

Native TIMP-2 from human rheumatoid synovial fibroblast. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stoichiometric complex with latent and active MMPs. Shown to inhibit the activities of MMP-1, MMP-2, MMP-12, and transin.
Native TIMP-2 from human rheumatoid synovial fibroblast. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stoichiometric complex with latent and active MMPs. Shown to inhibit the activities of MMP-1, MMP-2, MMP-12, and transin.

Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-1
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Physical form

In 200 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% BRIJ® 35 Detergent, pH 7.0.

Preparation Note

Prepared from fibroblasts that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Greene, J., et al. 1996. J. Biol. Chem. 271, 30375.
Miyazaki, K., et al. 1993. J. Biol. Chem. 268, 14387.

Legal Information

Brij is a registered trademark of Croda International PLC
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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