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581500

Sigma-Aldrich

TEMPOL

≥97% total nitrogen (N) basis, crystals,powder, free radical scavenger and nitric oxide spin trap, Calbiochem®

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Synonym(s):
TEMPOL, 4-Hydroxy-TEMPO, 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl
Empirical Formula (Hill Notation):
C9H18NO2
CAS Number:
2226-96-2
Molecular Weight:
172.24
MDL number:
MFCD00006478
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥97% total nitrogen (N) basis

form

crystals
powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

DMSO: 5 mg/mL
ethanol: soluble
water: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3

InChI key

UZFMOKQJFYMBGY-UHFFFAOYSA-N

General description

A stable, cell-permeable nitroxide free radical that acts as a radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.
A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Free radical scavenger and nitric oxide spin trap
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Prepare fresh solutions. Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Gariboldi, M.B., et al. 2000. Free Radic. Biol. Med.29, 633.
Miura, Y., et al. 2000. J. Radiat. Res. (Tokyo)41, 103.
Mota-Filipe, H., et al. 1999. Shock 12, 255.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H302,H318,H373

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2 Oral

Target Organs

Liver,spleen

WGK

WGK 1

Flash Point(F)

294.8 °F

Flash Point(C)

146 °C

Certificates of Analysis (COA)

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