575310
T0901317
A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXRα).
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Synonym(s):
T0901317, TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide
Empirical Formula (Hill Notation):
C17H12F9NO3S
CAS Number:
Molecular Weight:
481.33
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
light beige
solubility
DMSO: 50 mg/mL
ethanol: 50 mg/mL
shipped in
wet ice
storage temp.
−20°C
InChI
1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChI key
SGIWFELWJPNFDH-UHFFFAOYSA-N
General description
A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.
A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.
Biochem/physiol Actions
Cell permeable: yes
EC50 = 20 nM for LXRα
Primary Target
Liver X receptor (LXRα)
Liver X receptor (LXRα)
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Harmful (C)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Terasaka, N., et al. 2003. FEBS Lett.536, 6.
Cao, G., et al. 2002. J. Biol. Chem.278, 1131.
Field, F.J., et al. 2002. Biochem. J.368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem.277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 1477.
Repa, J.J., et al. 2000. Science289, 1524.
Schultz, J.R., et al. 2000. Genes Dev.14, 2831.
Cao, G., et al. 2002. J. Biol. Chem.278, 1131.
Field, F.J., et al. 2002. Biochem. J.368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem.277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 1477.
Repa, J.J., et al. 2000. Science289, 1524.
Schultz, J.R., et al. 2000. Genes Dev.14, 2831.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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