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Key Documents

573098

Sigma-Aldrich

JAK2 Inhibitor III, SD-1029

The JAK2 Inhibitor III, SD-1029, also referenced under CAS 118372-34-2, controls the biological activity of JAK2.

Synonym(s):

JAK2 Inhibitor III, SD-1029, 9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione, 2HBr, NSC 371488

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500 MG
¥1,592.92

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500 MG
¥1,592.92

About This Item

Empirical Formula (Hill Notation):
C25H30Cl2N2O3 · 2HBr
CAS Number:
118372-34-2
Molecular Weight:
639.25
MDL number:
MFCD24702860
UNSPSC Code:
12352200
NACRES:
NA.77

¥1,592.92

Available to ship on2025年4月27日Details

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Quality Level

100

Assay

≥80% (sum of isomers, HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

off-white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

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technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

-

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

format

neat

format

single component solution

format

-

format

-

Quality Level

300

Quality Level

300

Quality Level

100

Quality Level

200

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material

grade

-

grade

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

10-30°C

storage temp.

-

General description

A cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of Jak1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in cell-free kinase assays at a concentration of 10 µM. Effectively inhibits cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Duan, Z., et al. 2006. Clin. Cancer Res.12, 6844.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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