567430
Sodium Butyrate
A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway.
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Synonym(s):
Sodium Butyrate, Butyric Acid, Na, NaB, HDAC Inhibitor V
Empirical Formula (Hill Notation):
C4H7NaO2
Recommended Products
Quality Level
Assay
≥98% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 2 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChI key
MFBOGIVSZKQAPD-UHFFFAOYSA-M
General description
A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Reduces histamine-induced calcium mobilization in C6 glioma cells. Down-regulates the activity of the serine/threonine protein kinase casein kinase II in HT29 cells.
A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protein kinase casein kinase II in HT29 cells.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Induce apoptosis
Induce apoptosis
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Irritant (B)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ou, H.C., et al. 1997. Neuroreport 8, 1375.
Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
Krupitza, G., et al. 1995. Carcinogenesis16, 1199.
Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun.195, 31.
Hague, A., et al. 1993. Int. J. Cancer55, 498.
Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
Krupitza, G., et al. 1995. Carcinogenesis16, 1199.
Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun.195, 31.
Hague, A., et al. 1993. Int. J. Cancer55, 498.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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