All Photos(1)
Synonym(s):
InSolution Sinefungin, SF, Adenosyl-ornithine, A9145
Empirical Formula (Hill Notation):
C15H23N7O5
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
storage temp.
−20°C
InChI
1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
InChI key
LMXOHSDXUQEUSF-YECHIGJVSA-N
General description
An anti-leishmanial nucleoside antibiotic that acts as an S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase-specific inhibitor.
Biochem/physiol Actions
Primary Target
S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase
S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase
Warning
Toxicity: Standard Handling (A)
Physical form
A 10 mM (2 mg/524 µl) solution in H₂O.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Lin, Q., et al. 2001. J. Am. Chem. Soc.123, 11608.
Zingg, J.M., et al. 1996. Nucleic Acids Res.24, 3267.
McCammon, M.T., and Parks, L.W. 1981. J. Bacteriol.145, 106.
Pugh, C.S.G., et al. 1978. J. Biol. Chem.253, 4075.
Lin, Q., et al. 2001. J. Am. Chem. Soc.123, 11608.
Zingg, J.M., et al. 1996. Nucleic Acids Res.24, 3267.
McCammon, M.T., and Parks, L.W. 1981. J. Bacteriol.145, 106.
Pugh, C.S.G., et al. 1978. J. Biol. Chem.253, 4075.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
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