566327
SIRT1/2 Inhibitor VII
The SIRT1/2 Inhibitor VII, also referenced under CAS 143034-06-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
SIRT1/2 Inhibitor VII, 5-(2-Naphthylidine)-2-thiobarbituric acid, SIRT1 Inhibitor V, SIRT2 Inhibitor VII
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About This Item
Empirical Formula (Hill Notation):
C15H10N2O2S
CAS Number:
Molecular Weight:
282.32
UNSPSC Code:
12352200
Quality Level
Assay
≥95% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to off-white
solubility
DMSO: 3 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A thiobarbiturate compound that acts as an inhibitor against sirtuins (IC50 = 13.2 & 9.1 µM using human SIRT1 & SIRT2, respectively), the NAD+-dependent class III histone deacetylases (HDACs). Computer-aided molecular structural anaylsis reveals that both hydrogen bonds and van der Waals type of interactions contribute to the successful docking of the inhibitor into the nicotinamde subpocket of SIRT2 with the bulky naphthyl group being placed directly into the acetyllysine substrate channel.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Uciechowska, U., et al. 2008. ChemMedChem3, 1965.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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