559418
SBHA
A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties.
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Synonym(s):
SBHA, Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
Empirical Formula (Hill Notation):
C8H16N2O4
Recommended Products
Quality Level
Assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
InChI key
IDQPVOFTURLJPT-UHFFFAOYSA-N
General description
A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Causes an increase in acetylated histone H4 in MEL cells and inhibits the human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that acts both as inducers of differentiation of transformed cells and apoptosis. Suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).
A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that induce both differentiation of transformed cells and apoptosis. Shown to suppress the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
human HDAC1 and HDAC3 activities
human HDAC1 and HDAC3 activities
Product does not compete with ATP.
Reversible: no
Target IC50: 11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
From Catalog:
Desc. Field- added "cell-permeable"
From Catalog:
Desc. Field- added "cell-permeable"
Other Notes
Brinkmann, H., et al. 2001. J. Biol. Chem.276, 22491.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA91, 10251.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA91, 10251.
Legal Information
Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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