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COA/COQ

559393-M

SB 202190, Hydrochloride

Name: SB 202190, Hydrochloride
Brand: MM

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.

Synonym(s):

SB 202190, Hydrochloride, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₄FN₃O · xHCl

CAS Number:

350228-36-3

Molecular Weight:

331.34 (free base basis)

UNSPSC Code:

12352200

Quality Level

100

Assay

≥97% (HPLC)

form

solid

potency

16 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

amber

solubility

water: 0.5 mg/mL (slightly soluble)
DMSO: soluble

storage temp.

−20°C

InChI

1S/C20H14FN3O.ClH/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;/h1-12,25H,(H,23,24);1H

InChI key

XOQSUTIMRLPFPB-UHFFFAOYSA-N

General description

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

Biochem/physiol Actions

Target IC₅₀: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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