557404-M
RNA Polymerase III Inhibitor
InSolution, ≥97%
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Synonym(s):
InSolution RNA Polymerase III Inhibitor, 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide, N-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide
Empirical Formula (Hill Notation):
C19H15Cl2N3O2S2
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
liquid
potency
27 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
storage temp.
−70°C
InChI
1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
InChI key
BVBDTTLISMIOJY-UHFFFAOYSA-N
General description
A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. The solid form of this compound (Cat. No. 557403) is also available.
Biochem/physiol Actions
Primary Target
RNA Polymerase III
RNA Polymerase III
Warning
Toxicity: Standard Handling (A)
Physical form
A 25 mM (5 mg/442 µL) solution of RNA Polymerase III Inhibitor (Cat. No. 557403) in DMSO.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Other Notes
Wu, L., et al. 2003. Euk. Cell2, 256.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Certificates of Analysis (COA)
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