All Photos(1)
Synonym(s):
RNAi Enhancer, Enoxacin Sodium Salt, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt
Empirical Formula (Hill Notation):
C15H16FN4NaO3
Recommended Products
Assay
≥97% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white to off-white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A fluoroquinolone antibacterial compound that displays antitumor properties. Shown to bind to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP; Kd = 12.56 µM), enhance RNAi and stimulate miRNA expression. Specifically induces cell-cycle arrest and apoptosis in a panel of 12-cancer cells (EC50 of 124 µM in HCT-116 cells) and suppresses tumor growth in a xenograft mouse model (10 mg/kg, i.p.).
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Other Notes
Melo, S., et al. 2011. Proc. Natl. Acad. Sci. USA108, 4394.
Zhang, Q., et al. 2008. Cell Res.18, 1077.
Shan, G., et al. 2008. Nat. Biotechnol.26, 933.
Zhang, Q., et al. 2008. Cell Res.18, 1077.
Shan, G., et al. 2008. Nat. Biotechnol.26, 933.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Francesco Greco et al.
Non-coding RNA, 9(3) (2023-06-27)
Virus-encoded microRNAs were first reported in the Epstein-Barr virus in 2004. Subsequently, a few hundred viral miRNAs have been identified, mainly in DNA viruses belonging to the herpesviridae family. To date, only 30 viral miRNAs encoded by RNA viruses are
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