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557303

Sigma-Aldrich

Rifampicin

≥97% (HPLC), powder (or crystals), RNA polymerase inhibitor, Calbiochem®

Synonym(s):

Rifampicin, Rifampin, 3-(4-Methylpiperazinyliminomethyl)rifamycin SV

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About This Item

Empirical Formula (Hill Notation):
C43H58N4O12
CAS Number:
13292-46-1
Molecular Weight:
822.94
MDL number:
MFCD00151389
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Rifampicin, Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.

Quality Level

100

Assay

~97-102% (by Assay)

form

powder (or crystals)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

red-brown

shipped in

ambient

storage temp.

−20°C

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

General description

Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.
Antibiotic that specifically inhibits DNA-dependent bacterial RNA polymerase by forming an inactive complex with RNA polymerase. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.

Biochem/physiol Actions

Primary Target
DNA-dependent RNA polymerase in bacteria

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C.

Other Notes

Jin, D.J. and Turnbough, Jr., C.L. 1994. J. Mol. Biol. 236, 72.
Levin, M.E. and Hatfull, G.F. 1993. Mol. Microbiol. 8, 277.
Wehrli, W., et al. 1968. Proc. Natl. Acad. Sci. USA61, 667.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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