All Photos(2)

Documents

553512

Rac1 Inhibitor II, Z62954982

Name: Rac1 Inhibitor II, Z62954982
Brand: MM

InSolution, ≥93%

Synonym(s):

InSolution Rac1 Inhibitor II, Z62954982, Z62954982, 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide

Sign Into View Organizational & Contract Pricing

All Photos(2)

About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁N₃O₅S

CAS Number:

1090893-12-1

Molecular Weight:

415.46

MDL number:

MFCD11736677

UNSPSC Code:

12352200

NACRES:

NA.77

Quality Level

100

Assay

≥93% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

shipped in

ambient

storage temp.

−20°C

SMILES string

CC1=CC=C(NC(C2=CC(OCC3=C(C)ON=C3C)=CC=C2)=O)C=C1S(N)(=O)=O

General description

A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). The solid form of this compound (Cat. No. 553511) is also available.

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 100 mM (10 mg/241 µl) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Ferri, N., et al. 2009. J. Med. Chem.52, 4087.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

(refers to pure substance)

Flash Point(C)

(refers to pure substance)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Transcriptome analysis of cardiac endothelial cells after myocardial infarction reveals temporal changes and long-term deficits.

Chitra Basu et al.

Scientific reports, 14(1), 9991-9991 (2024-05-02)

Endothelial cells (ECs) have essential roles in cardiac tissue repair after myocardial infarction (MI). To establish stage-specific and long-term effects of the ischemic injury on cardiac ECs, we analyzed their transcriptome at landmark time points after MI in mice. We

p53 directs leader cell behavior, migration, and clearance during epithelial repair.

Kasia Kozyrska et al.

Science (New York, N.Y.), 375(6581), eabl8876-eabl8876 (2022-02-11)

Epithelial cells migrate across wounds to repair injured tissue. Leader cells at the front of migrating sheets often drive this process. However, it is unclear how leaders emerge from an apparently homogeneous epithelial cell population. We characterized leaders emerging from

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service