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Merck
CN

551850

Quinacrine dihydrochloride

A non-specific phospholipase A2 (PLA2) inhibitor.

Synonym(s):

Mepacrine, 6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H30ClN3O · 2HCl
CAS Number:
69-05-6
Molecular Weight:
472.88
NACRES:
NA.77
UNSPSC Code:
12352101
Beilstein/REAXYS Number:
4834013
MDL number:
MFCD00012659

Key Documents

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Product Name

Quinacrine dihydrochloride, A non-specific phospholipase A2 (PLA2) inhibitor.

SMILES string

Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13

InChI key

UDKVBVICMUEIKS-UHFFFAOYSA-N

InChI

1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H

description

Merck USA index - 14, 8044

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

yellow

solubility

water: soluble

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

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Biochem/physiol Actions

Cell permeable: no
Non-selective MAO-A/B inhibitor.
Product does not compete with ATP.
Reversible: no
Target IC50: 4.4 µM in suppressing glibenclamide-sensitive K+-currents

Disclaimer

Toxicity: Harmful (C)

General description

A non-specific phospholipase A2 (PLA2) inhibitor. Acts as an acetylcholine receptor antagonist. Suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 µM). Also inhibits monoamine oxidase (MAO).

Other Notes

Holscher, C. 1995. Neurobiol. Learn. Mem. 63, 206.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther.262, 1161.
Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev.21, 33.
Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 714.

Preparation Note

Stock solutions are stable for up to 60 h at 20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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