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1-Methyl-2-pyrrolidone

for liquid chromatography LiChrosolv®

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Synonym(s):
1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone
Empirical Formula (Hill Notation):
C5H9NO
CAS Number:
872-50-4
Molecular Weight:
99.13
MDL number:
MFCD00003193
UNSPSC Code:
41116105
EC Index Number:
212-828-1
NACRES:
NA.03

vapor pressure

0.32 hPa ( 20 °C)

Quality Level

100

product line

LiChrosolv®

grade

isocratic

Assay

≥99.5% (GC)

form

liquid

autoignition temp.

245 °C

expl. lim.

1.3-9.5 % (v/v)

technique(s)

HPLC: suitable

impurities

≤0.05% Water

transmittance

300 nm, ≥50%
325 nm, ≥90%
350 nm, ≥97%
400 nm, ≥99%

pH

8.5-10.0 (20 °C, 100 g/L in H2O)

bp

202 °C/1013 hPa

mp

-24 °C

transition temp

flash point 91 °C

solubility

1000 g/L

density

1.03 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

Related Categories

Application


  • Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine: This study utilizes 1-Methyl-2-pyrrolidone (NMP) as a high-purity solvent in the formulation of a transdermal bioadhesive system, enhancing the solubility and delivery of antimalarial drugs. The application highlights NMP′s role in pharmaceutical formulations, particularly in improving drug efficacy and patient compliance (Volpe-Zanutto et al., 2021).

Analysis Note

Purity (GC): ≥ 99.5 %
Water: ≤ 0.05 %
Transmission (at 300 nm): ≥ 50 %
Transmission (at 325 nm): ≥ 90 %
Transmission (at 350 nm): ≥ 97 %
Transmission (at 400 nm): ≥ 99 %

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markHealth hazard
GHS07,GHS08

Signal Word

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

195.8 °F - Pensky-Martens closed cup

Flash Point(C)

91 °C - Pensky-Martens closed cup

Certificates of Analysis (COA)

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