540211
PTP Inhibitor IV
The PTP Inhibitor IV, also referenced under CAS 329317-98-8, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
PTP Inhibitor IV, bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene, Protein Tyrosine Phosphatase Inhibitor IV
Empirical Formula (Hill Notation):
C26H26F6N2O4S2
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to off-white
solubility
DMSO: 10 mg/mL
acetonitrile: soluble
shipped in
ambient
storage temp.
2-8°C
General description
An uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases (PTP; IC50 = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-ς, PTP-β, and PTP-µ, respectively).
An uncharged, 1,4-di-substituted, phenyl-linked, bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, substrate competitive, active-site-directed inhibitor of protein tyrosine phosphatases (PTP). Reported to inhibit SHP-2 (IC50 = 1.8 µM), PTP1B (IC50 = 2.5 µM), PTP-ε (IC50 = 8.4 µM), PTP-Meg-2 (IC50 = 13 µM), PTP-ς (IC50 = 20 µM), PTP-β (IC50 = 6.4 µM), and PTP-µ (IC50 = 6.7 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
SHP-2
SHP-2
Product competes with ATP.
Reversible: yes
Target IC50: 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Huang, P., et al. 2003. Bioorg. Med. Chem.11, 1835.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
D G Semaan et al.
Journal of ethnopharmacology, 203, 39-46 (2017-03-28)
Ethno-botanical information from diabetic patients in Cuba led to the identification of Allophylus cominia as a possible source of new drugs for the treatment of type 2 diabetes mellitus (T2-DM). Chemical characterization of the extracts from A. cominia was carried
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service