All Photos(1)
Synonym(s):
InSolution PTP1B Inhibitor, PTP Inhibitor XXII
Empirical Formula (Hill Notation):
C26H19Br2N3O7S3
Molecular Weight:
741.45
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.
Biochem/physiol Actions
Cell permeable: yes
IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Physical form
A 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Certificates of Analysis (COA)
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