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539509

Sigma-Aldrich

Anti-PP2A/A (7-19) (PR65) Rabbit pAb

liquid, Calbiochem®

Synonym(s):

Anti-PP2A/A

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity (predicted by homology)

mammals

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG

shipped in

wet ice

storage temp.

−70°C

target post-translational modification

unmodified

Gene Information

human ... PTPA(5524)

General description

Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~65 kDa α- and β-isoforms of the A(PR65) regulatory subunit of PP2A.

Immunogen

Mammalian
a synthetic peptide (DDSLYPIAVLIDE) corresponding to amino acids 7-19 of the mammalian PP2A/A regulatory subunit, conjugated to KLH

Application

Immunoblotting (1:500)

Immunocytochemistry (1:500)

Warning

Toxicity: Standard Handling (A)

Physical form

In 10 mM Tris-HCl, 3 mM glycine, pH 7.5.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Cross-reacts with PR65 from most mammalian species, including human, rat, and mouse. Exhibits minor cross-reactivity with tubulin in whole brain homogenates. Variables associated with assay conditions will dictate the proper working dilution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sean C Little et al.
Science signaling, 8(386), ra72-ra72 (2015-07-23)
Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme composed of a catalytic, scaffolding, and regulatory subunit. In the heart, PP2A activity is requisite for cardiac excitation-contraction coupling and central in adrenergic signaling. We found that mice deficient in the PP2A
Sean T DeGrande et al.
The Journal of biological chemistry, 288(2), 1032-1046 (2012-12-04)
Kinase/phosphatase balance governs cardiac excitability in health and disease. Although detailed mechanisms for cardiac kinase regulation are established, far less is known regarding cardiac protein phosphatase 2A (PP2A) regulation. This is largely due to the complexity of the PP2A holoenzyme

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