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Sigma-Aldrich

Protein Methyltransferase Inhibitor, AMI-5

The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Protein Methyltransferase Inhibitor, AMI-5, Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III

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About This Item

Empirical Formula (Hill Notation):
C29H6Br4Na2O5 · 3H2O
CAS Number:
17372-87-1
Molecular Weight:
854.00
MDL number:
MFCD00005040
UNSPSC Code:
12171500
NACRES:
NA.54

Quality Level

100

Assay

≥90%

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

red-brown

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2

InChI key

SEACYXSIPDVVMV-UHFFFAOYSA-L

General description

A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Other Notes

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

WGK

WGK 3

Flash Point(F)

Pensky-Martens closed cup

Flash Point(C)

Pensky-Martens closed cup

Certificates of Analysis (COA)

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