5.38384
NCK/PAK Blocking Peptide
Synonym(s):
NCK/PAK Blocking Peptide, TAT-PAK peptide, NCK blocking peptide
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About This Item
Empirical Formula (Hill Notation):
C126H221N51O32S2 · 11C2HF3O2 · 7H2O
Molecular Weight:
4406.92
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
solid
potency
2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
off-white
solubility
water: 100 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
NCK
NCK
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable synthetic peptide derived from the proline-rich region near the N-terminal of p21 activated kinase1 (PAK1) and fused with HIV TAT. Shown to selectively binds to the non-catalytic region of tyrosine kinase adaptor protein (NCK) and disrupts the cellular transport and localization of PAK. Shown to specifically inhibit endothelial cell migration and contractility (IC50 = 2 µM) and block bFGF-induced angiogenesis in a chick chorioallantoic membrane (CAM) assay. Does not exhibit any deleterious effects on endothelial cell survival and growth.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Other Notes
Chen, J., et al. 2015, Sci. Signal.8, 365.
Kiosses, W., et al. 2002, Circ. Res.90, 697.
Kiosses, W., et al. 2002, Circ. Res.90, 697.
H2N-YGRKKRRQRRRGKPPAPPMRNTSTM-C02H
Packaging
Packaged under inert gas
Physical form
Supplied as TFA salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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