All Photos(1)
Synonym(s):
PI4KIIIβ Inhibitor, BF738735, 2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
Empirical Formula (Hill Notation):
C21H19FN4O3S
Recommended Products
Assay
≥98% (HPLC)
Quality Level
form
powder
potency
5.7 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
light gray
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
General description
A cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC50 = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC50 = 1.7 µM) and several other lipid kinases (IC50 >10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC50 = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PI4KIII&beta
PI4KIII&beta
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Strating, J.R.P.M., et al. 2015. Cell Reports.10, 600.
MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett.4, 585.
MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett.4, 585.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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