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ALDH1A1, A37

Name: ALDH1A1, A37
Brand: MM

Synonym(s):

ALDH1A1, A37, thieno[3,2-d]pyrimidin-2-yl]thio}acetate, Acetaldehyde Dehydrogenase 1A1 inhibitor, A37

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₅N₃O₃S₂

CAS Number:

896795-60-1

Molecular Weight:

431.57

MDL number:

MFCD15085544

UNSPSC Code:

12352200

Assay

≥97% (HPLC)

Quality Level

100

form

solid

potency

4.6 μM IC₅₀
300 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 50 mg/mL

storage temp.

−20°C

SMILES string

O=C1N(CCCN2CCCC2)C(SCC(OCC)=O)=NC3=C1SC4=C3C=CC=C4

General description

A cell permeable benzothieno[3,2-d]pyrimidone derivative that acts as a selective, substrate competitive inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; K_i = 300 nM; IC₅₀ = 4.6 µM) in ovarian cancer spheroids. Does not affect the activity of other related orthologs, including ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1 even at higher concentrations (>100 µM). Enhances sensitization of IGROV1 ovarian carcinoma cells to cisplatin. Disrupts spheroid formation and reduces viability of ovarian cancer cells.

A cell permeable benzothieno[3,2-d]pyrimidone derivative that acts as a selective, substrate competitive inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; K_i = 300 nM; IC₅₀ = 4.6 µM) in ovarian cancer spheroids. Does not affect the activity of other related orthologs, including ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1 even at higher concentrations (>100 µM). Enhances sensitization of IGROV1 ovarian carcinoma cells to cisplatin. Disrupts spheroid formation and reduces viability of ovarian cancer cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell permeable, selective, substrate competitive inhibitor of aldehyde dehydrogenae 1A1 (ALDH1A1; K_i = 300 nM; IC₅₀ = 4.6 µM). Does not affect the activity of other related orthologs.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
ALDH1A1

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Condello, S., et al. 2014. Oncogene.33, in press.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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