All Photos(1)
Synonym(s):
S1P Receptor 2 Agonist, CYM-5520, S1PR2 Agonist, CYM-5520, Sphingosine-1-Phosphate Receptor 2 Agonist, CYM 5520, EDG5 Agonist
Empirical Formula (Hill Notation):
C21H19N3O2
Recommended Products
Assay
≥98% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
General description
A pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. Does not affect the activity of S1PR1, 3, and 5 and the activity of 29 other receptors and transports in any significant manner. Acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).
A pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. Does not affect the activity of S1PR1, 3, and 5 and the activity of 29 other receptors and transports in any significant manner. Acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
S1PR2
S1PR2
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).
Other Notes
Satsu, H., et al. 2013. Bioorg. Med. Chem.21, 5373.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Hideo Satsu et al.
Bioorganic & medicinal chemistry, 21(17), 5373-5382 (2013-07-16)
Molecular probe tool compounds for the Sphingosine 1-phosphate receptor 2 (S1PR2) are important for investigating the multiple biological processes in which the S1PR2 receptor has been implicated. Amongst these are NF-κB-mediated tumor cell survival and fibroblast chemotaxis to fibronectin. Here
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