530050-M
PRIMA-1
A cell-permeable quinuclidinone analog with antitumor properties.
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Synonym(s):
PRIMA-1, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
Empirical Formula (Hill Notation):
C9H15NO3
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Quality Level
Assay
≥95% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
off-white
solubility
water: 2 mg/mL
storage temp.
2-8°C
InChI
1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
InChI key
RFBVBRVVOPAAFS-UHFFFAOYSA-N
General description
A cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.
A cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.
Biochem/physiol Actions
Primary Target
Restores biochemical and biological function to mutant p53
Restores biochemical and biological function to mutant p53
Warning
Toxicity: Standard Handling (A)
Other Notes
Bykov, V.J., et al. 2002. Nat. Med.8, 282.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Resp. Sens. 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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