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528906

Millipore

Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded

Known to induce interferon production. Hypochromicity: ≥40% at 248 nm. Extinction coefficient = 5000 M-1cm-1 at 260 nm, pH 7.0.

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Synonym(s):
Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded, Poly I • poly C, Na
CAS Number:
42424-50-0
MDL number:
MFCD00131984
UNSPSC Code:
12352208
NACRES:
NA.51

Quality Level

100

Assay

≥99% (TLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

aqueous buffer: 10 mg/mL
water: soluble

shipped in

ambient

storage temp.

−20°C

General description

Hypochromicity: ≥40% at 248 nm.
Known to induce interferon production.

Application


  • Penaeus monodon Interferon Regulatory Factor (PmIRF) Activates IFNs and Antimicrobial Peptide Expression via a STING-Dependent DNA Sensing Pathway.: This study explores the role of PmIRF in shrimp immune responses, specifically how it activates interferons and antimicrobial peptides through the STING-dependent DNA sensing pathway, enhancing antiviral defenses. (Soponpong et al., 2021).

  • Identification, expression profiling of a grass carp TLR8 and its inhibition leading to the resistance to reovirus in CIK cells.: This article focuses on the TLR8 receptor in grass carp, its expression profiles, and how its inhibition confers resistance to reovirus in fish cell lines, providing insights into antiviral immunity in aquatic species. (Chen et al., 2013).

  • Identification and expression profiles of ADAR1 gene, responsible for RNA editing, in responses to dsRNA and GCRV challenge in grass carp (Ctenopharyngodon idella).: The study examines the ADAR1 gene involved in RNA editing in grass carp, highlighting its response to double-stranded RNA and grass carp reovirus, shedding light on fish immune mechanisms. (Yang et al., 2012).

  • Immune activation and target organ damage are consequences of hydrodynamic treatment but not delivery of naked siRNAs in mice.: This research differentiates the effects of hydrodynamic treatment and naked siRNA delivery in mice, showing that immune activation and organ damage are associated with the treatment method rather than the siRNAs themselves. (Rácz et al., 2011).

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Xiang Chen et al.
Cellular & molecular immunology, 17(1), 76-84 (2018-10-03)
Epigenetic modification, including histone modification, precisely controls target gene expression. The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and type I interferons has been fully elucidated, whereas the roles of histone modification alteration and epigenetic modifiers in

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