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528282

Sigma-Aldrich

Polo-like Kinase Inhibitor I

The Polo-like Kinase Inhibitor I, also referenced under CAS 916985-21-2, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Polo-like Kinase Inhibitor I, 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(4-methanesulfonyl-benzyloxy)-thiophene-2-carboxamide, Plk Inhibitor I, Plk Inhibitor I, 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(4-methanesulfonyl-benzyloxy)-thiophene-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C22H21N3O6S2
CAS Number:
916985-21-2
Molecular Weight:
487.55
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

tan

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)

InChI key

YYZTVTZCYVZGRB-UHFFFAOYSA-N

General description

A thiophenecarboxamide compound that acts as a potent and ATP-binding site-targeting inhibitor of polo-like kinase 1 (IC50 = 126 nM) with excellent selectivity over IKK-2 and IKK-3 (IC50 >16 µM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Polo-like Kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 126 nM against polo-like kinase 1

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Bamborough, P., et al. 2006. Bioorg. Med. Chem. Lett.16, 6236.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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