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Sigma-Aldrich

Plasminogen Activator Inhibitor-1, Mutant

from Recombinant, ≥95% (SDS-PAGE), liquid, PAI-1 inhibitor, Calbiochem®

Synonym(s):

PAI-1, Mutant

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

product name

Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant, The Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant controls the biological activity of Plasminogen Activator. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Quality Level

100

Assay

≥95% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

General description

Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t½ = 145 h at 37°C, pH 7.4). Inhibits uPA (Ki = 5.1 x 106 M-1sec-1) and tPA (Ki = 7.9 x 105 M-1sec-1).
Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t½ = 145 hours at 37°C, pH 7.4). Inhibits uPA (Ki = 5.1 x 106 M-1 sec-1) and tPA (Ki = 7.9 x 105 M-1 sec-1).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Plasminogen Activator
Product does not compete with ATP.
Reversible: no
Target Ki: 5.1 x 106 M-1 sec-1, 7.9 x 105 M-1 sec-1 against uPA and tPA, respectively

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 50 mM sodium phosphate buffer, 1 mM EDTA, pH 6.6.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Berkenpas, M.B., et al. 1995. EMBO J. 14, 2969.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C Bouarab et al.
Molecular psychiatry, 26(9), 4968-4981 (2021-01-30)
Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition.

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