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528105

Sigma-Aldrich

Picrotoxin, Anamirta cocculin

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

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Synonym(s):
Picrotoxin, Anamirta cocculin
Empirical Formula (Hill Notation):
C15H18O7 · C15H16O6
CAS Number:
124-87-8
Molecular Weight:
602.58
MDL number:
MFCD00074824
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (mixture of Picrotoxin and picrotin, HPLC)

form

crystals
powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to light yellow

solubility

aqueous base: 3 mg/mL
ethanol: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1

InChI key

VJKUPQSHOVKBCO-ZTYBEOBUSA-N

General description

A potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl– channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.
A potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl- channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

Biochem/physiol Actions

Cell permeable: no
Primary Target
GABA receptors
Product does not compete with ATP.
Reversible: no
Target IC50: 240 nM against GABA receptors

Warning

Toxicity: Highly Toxic (H)

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol.464, 423.
Akaike, N., et al. 1985. Experientia41, 70.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Hazard Classifications

Acute Tox. 2 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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