524718
Phosphodiesterase Inhibitor Set I
The Phosphodiesterase Inhibitor Set I controls the activity of Phosphodiesterase. This small molecule/inhibitor is primarily used for Cell Signaling applications.
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Synonym(s):
PDE Inhibitor Set
UNSPSC Code:
12352200
Recommended Products
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
shipped in
ambient
storage temp.
2-8°C
General description
A convenient set of inhibitors that are selective for PDE types I, III, IV, and V. Contains 10 mg of 8-Methoxymethyl-3-isobutyl-1-methylxanthine (Cat. No. 454202), a Ca2+/CaM-dependent PDE (PDE I) inhibitor; 1 mg of 4-{[3′,4′-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline (Cat. No. 475250), a cGMP-specific PDE (PDE V) inhibitor; 5 mg of Rolipram (Cat. No. 557330), a cAMP-specific PDE (PDE IV) inhibitor; and 10 mg of Trequinsin, Hydrochloride (Cat. No. 382425), a cGMP-inhibited PDE (PDE III) inhibitor. Supplied with data sheet.
Phosphodiesterases (PDEs) play an important role in the regulation of cAMP and cGMP levels in the cell. At least five PDE isozymes have been characterized that are differentially expressed and regulated in different cell types: Ca2+-calmodulin-dependent (PDE I); cGMP-stimulated (PDE II); cGMP-inhibited (PDE III); cAMP-specific (PDE IV); cGMP-specific (PDE V). These isozymes exhibit significant homology in their catalytic domain. The cyclic nucleotides are important regulators of many different cellular processes. They are involved in inflammation, asthma, and cardiovascular complications. Hence, specific inhibitors of the PDE isozymes have a potential for use as therapeutic agents. The Phosphodiesterase Inhibitor Set I contains the following inhibitors that are selective for PDE types l, III, IV, and V:
• 8-Methoxymethyl-3-isobutyl-1-methylxanthine(8-Methoxymethyl-IBMX) (Cat. No. 454202), 10 mg
• 4-{[3′,4′-(Methylenedioxy) benzyl]amino}-6-methoxyquinazoline (Cat. No. 475250), 1 mg
• Rolipram (Cat. No. 557330), 5 mg
• Trequinsin, Hydrochloride (Cat. No. 382425), 10 mg
• 8-Methoxymethyl-3-isobutyl-1-methylxanthine(8-Methoxymethyl-IBMX) (Cat. No. 454202), 10 mg
• 4-{[3′,4′-(Methylenedioxy) benzyl]amino}-6-methoxyquinazoline (Cat. No. 475250), 1 mg
• Rolipram (Cat. No. 557330), 5 mg
• Trequinsin, Hydrochloride (Cat. No. 382425), 10 mg
Biochem/physiol Actions
Primary Target
PDE I, PDE III, PDE IV, PDE V
PDE I, PDE III, PDE IV, PDE V
Warning
Toxicity: Multiple Toxicity Values, refer to MSDS (O)
Reconstitution
Following reconstitution of each inhibitor, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
See properties table for specific solvent and recommended stock concentration.
Takase, Y., et al. 1994. J. Med. Chem.37, 2106.
Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther.270, 250.
Wells, J.N. and Miller, J.R. 1988. Methods Enzymol.159, 489.
Ruppert, D. and Weithmann, K.U. 1982. Life Sciences31, 2037.
Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther.270, 250.
Wells, J.N. and Miller, J.R. 1988. Methods Enzymol.159, 489.
Ruppert, D. and Weithmann, K.U. 1982. Life Sciences31, 2037.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Certificates of Analysis (COA)
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