Recommended Products
Assay
≥95% (SDS-PAGE)
form
liquid
General description
Native platelet factor 4 from human platelets. A heparin-binding chemokine released from α-granules of activated platelets. Binds to the newly formed blood vessels and reduces tumor neovascularization. Molecular weight = 7800-9000 (monomer).
Physical form
In 1.5 M NaCl, 20 mM Tris-HCl, pH 8.3.
Preparation Note
Prepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Y Sato et al.
Biochemical and biophysical research communications, 172(2), 595-600 (1990-10-30)
Platelet factor 4 (PF-4) blocked the binding of basic fibroblast growth factor (bFGF) to the plasma membrane receptor. Five micrograms/ml of PF-4 completely blocked the specific binding of bFGF to the receptor of NIH 3T3 cells. Endogenously produced bFGF regulates
Stephanie Pitsilos et al.
Thrombosis and haemostasis, 90(6), 1112-1120 (2003-12-04)
Emerging evidence supports a role for platelets in the progression of atherosclerosis in addition to an involvement in thrombotic vascular occlusion. Platelet Factor 4 (PF4), a chemokine released by activated platelets, stimulates several pro-atherogenic processes. Therefore, we examined the localization
D L Kolber et al.
Journal of the National Cancer Institute, 87(4), 304-309 (1995-02-15)
When administered locally, recombinant platelet factor 4 (rPF4), a known angiogenesis inhibitor, has been shown to effectively suppress murine melanoma and human colon carcinoma primary tumor growth in mice. It was tentatively concluded that this effect was due to the
C Ravanat et al.
European journal of biochemistry, 223(1), 203-210 (1994-07-01)
Platelet factor 4 is a heparin-binding protein released from the alpha granules of activated platelets. This study describes the purification and identification of two forms of rat platelet factor 4, the previously characterized non-glycosylated form of 7 kDa and an
M Cortellaro et al.
Thrombosis research, 58(6), 571-576 (1990-06-15)
The role of platelet activation in diabetic microangiopathy is still controversial. We evaluated the degree of platelet activation in relation to vessel wall damage in three selected, well matched groups of subjects (10 healthy controls; 20 insulin dependent diabetic patients
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service