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520222

Sigma-Aldrich

PPACK dihydrochloride

≥80% (HPLC), solid, thrombin inhibitor, Calbiochem®

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Synonym(s):
PPACK, Dihydrochloride
Empirical Formula (Hill Notation):
C21H31ClN6O3 · 2HCl
Molecular Weight:
523.88
UNSPSC Code:
12352200
NACRES:
NA.77

product name

PPACK, Dihydrochloride, PPACK, Dihydrochloride, CAS 142036-63-3, is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.

Quality Level

100

Assay

≥80% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

water: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C21H31ClN6O3.2ClH/c22-13-18(29)16(8-4-10-26-21(24)25)27-19(30)17-9-5-11-28(17)20(31)15(23)12-14-6-2-1-3-7-14;;/h1-3,6-7,15-17H,4-5,8-13,23H2,(H,27,30)(H4,24,25,26);2*1H/t15-,16+,17+;;/m1../s1

InChI key

XKDCRQWZLPWLFG-LKLBIAKRSA-N

General description

Extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H2O (Cat. No. 508773).
Extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator. Factor VIIa, and Factor XIa.

Biochem/physiol Actions

Cell permeable: no
Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin
Primary Target
Thrombin
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-D-Phe-Pro-Arg-chloromethylketone, 2HCl

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.

Other Notes

Rosado, J. A., et al. 2002. J. Biol. Chem.277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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