Skip to Content
Merck
CN
All Photos(1)

Documents

520219

Sigma-Aldrich

PPACK II trifluoroacetate salt

≥95% (HPLC), solid, kallikrein inhibitor, Calbiochem®

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
PPACK II, Trifluoroacetate Salt
Empirical Formula (Hill Notation):
C25H33ClN6O3 · 2C2HF3O2
CAS Number:
74392-49-7
Molecular Weight:
729.07
UNSPSC Code:
12352200
NACRES:
NA.77

product name

PPACK II, Trifluoroacetate Salt, Potent and specific irreversible inhibitor of plasma and glandular kallikreins.

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

off-white

solubility

water: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C25H33ClN6O3/c26-16-22(33)20(12-7-13-30-25(28)29)31-21(15-18-10-5-2-6-11-18)24(35)32-23(34)19(27)14-17-8-3-1-4-9-17/h1-6,8-11,19-21,31H,7,12-16,27H2,(H4,28,29,30)(H,32,34,35)/t19-,20+,21+/m1/s1

InChI key

UFXAQJOOAQICNE-HKBOAZHASA-N

General description

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H2O (Cat. No. 508573).
Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Plasma and glandular kallikreins
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

H-D-Phe-Phe-Arg-chloromethylketone, 2TFA

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service