516090-M
Penciclovir
A carba analog of Ganciclovir. Active against several herpes viruses. Induces apoptosis effectively without exerting much genotoxicity.
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Synonym(s):
Penciclovir, 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
Empirical Formula (Hill Notation):
C10H15N5O3
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL
aqueous buffer, pH 2.0: 10 mg/mL
storage temp.
−20°C
InChI
1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
InChI key
JNTOCHDNEULJHD-UHFFFAOYSA-N
General description
A carba analog of Ganciclovir (Cat. No. 345700). Active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
A synthetic acyclic guanine derivative and a carba analog of Ganciclovir (Cat. No. 345700) that is active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Other Notes
Leary, J.J., et al. 2002.Antimicrob. Agents Chemother.46, 762.
Amjad, M., et al. 2001. Microbiol. Immunol.45, 233.
Thust, R., et al. 2000. Cancer Gene Ther.7, 107.
Thust, R., et al. 1996. Antiviral Res.31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother.38, 719.
Harnden, M.R. 1989. J. Med. Chem.32, 1738.
Amjad, M., et al. 2001. Microbiol. Immunol.45, 233.
Thust, R., et al. 2000. Cancer Gene Ther.7, 107.
Thust, R., et al. 1996. Antiviral Res.31, 105.
Shaw, T., et al. 1994. Antimicrob. Agents Chemother.38, 719.
Harnden, M.R. 1989. J. Med. Chem.32, 1738.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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